SARS-CoV-2 Neutralizing Antibodies
| | To support COVID-19 research, Sino Biological has developed a large collection of antibodies against different antigens of SARS-CoV-2. These antibodies can be used to detect and/or neutralize the virus in a variety of assays including ELISA, western blot, immunofluorescent staining, immunohistochemistry, SPR (Biacore and Octet), pseudovirus infection, and potentially in vivo animal studies. | This week, Sino Biological announces the new additions to this product line:
The publication of SARS-CoV-2 antibody whitepaper.
The publication of SARS-CoV-2 antibody whitepaper.
The launch of two mouse mAbs with strong neutralizing activities.
These antibodies are SARS-CoV-2 specific, with no cross-reactivity with SARS-CoV, and other common coronaviruses.
The launch of a chimeric antibody specifically recognizing the S2 domain of SARS-CoV-2. | | | | | | | | Specific and Neutralizing Antibodies against SARS-CoV-2 Spike | | Cat # | 40591-MM43 | 40592-MM57 | | Description | Anti-Spike S1 | Anti-Spike RBD | | Type | Mouse MAb | Mouse MAb | | Ig Type | Mouse IgG1 | Mouse IgG2b | | Application | Neutralization, ELISA | Neutralization, ELISA | | | Neutralization Activity Assay | | Neutralizing antibodies can effectively inhibit the infection of SARS-CoV-2 Spike pseudovirus on ACE2 overexpression 293T cells. | | S1 Neutralizing Antibody | | RBD Neutralizing Antibody | | Conc. (µg/mL) | Inhibition% | Conc. (µg/mL) | Inhibition% | | 100 | 96.39% | 100 | 95.51% | | 10 | 94.57% | 10 | 93.32% | | 1 | 42.24% | 1 | 75.69% | | 0.1 | -5.53% | 0.1 | 10.11% | | | Competitive-ELISA Assay | | Neutralizing ability was detected by SARS-CoV-2 Inhibitor Screening ELISA Kit (Catalog# KIT001) using competitive ELISA. | | S1 Neutralizing Antibody | | RBD Neutralizing Antibody |  |  | | | Specificity Assay | | These two anti-spike antibodies have been tested against all seven coronaviruses, and are shown to be specific to SARS-CoV-2 spike. The reactivity of the antibodies against the known coronaviruses is assessed in ELISA. The reactivity (OD450) is illustrated in the figures below. | | S1 Neutralizing Antibody | | RBD Neutralizing Antibody |  |  | | | Antibody Against SARS-CoV-2 Spike S2 | | | |
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