​L1-beta Primes Innate Immunity

IL1-beta Primes Innate Immunity

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Friday 19 February 2021 View this email online

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The innate immunity, mediated by IL1 family proinflammatory cytokines, is the first line of defense against infections. Interleukin-1β (IL-1β), along with IL1-alpha and IL18, orchestrate the immune response through multiple downstream mechanisms. IL1-beta participates in the regulation of IL6 and TNF-alpha, and it also activates the vascular adhesion molecules ICAM1. IL1-beta transduces its signal through binding with the receptor IL1RI, which is complexed with the accessory protein IL1RACP. IL1-beta signaling is negatively regulated by the decoy receptor IL1-RII, and the receptor antagonist IL1RA. Sino Biological has developed a panel of recombinant IL-1β and IL-1β receptor reagents for the studying of the innate immune response.   Mature IL-1β Proteins Compared to the competing product, Sino Biological's IL-1β protein demonstrates a higher bioactivity as shown below. Induce Interferon Gamma Secretion >95% Purity Determined by SEC-HPLC Cat#: 50101-MNAE Cat#: 10139-HNAE List of Recombinant IL-1β 10139-H07E (Pro Form)   10139-HNAE (Mature Form)   50101-MNAE (Mature Form)   80023-R07E (Pro Form)   80023-RNAE (Mature Form)   65004-TNAE (Mature Form)   90010-CNAE (Mature Form)   62003-WNAE (Mature Form)   67002-UNAE (Mature Form)   70018-DNAE (Mature Form)   Note: H: Human; R: Rat; Ra: Rabbit; M: Mouse; C: Canine; Cy: Cynomolgus; P: Sus scrofa (Pig); F: Feline;     IL-1β Signaling Receptors • IL-1R1 & IL-1RACP: Induce downstream signaling cascade and gene transcription involved in inflammatory and immune pathways • IL-1R2: Decoy receptor   Receptor Antagonist • IL-1RA: Compete with IL1 to bind IL-1R1   Interleukin 1 alpha • IL-1α: Other important member of IL-1 family, shares some overlapping function with IL-1β. IL-1R1   IL-1RACP   IL-1R2   IL-1α   ELISA Antibody Pairs for IL-1β ELISA is the common technique to detect IL-1β protein. Sino Biological has developed several ELISA antibodies aganist IL-1β. Recommended ELISA Antibody Pair Capture: 10139-MM07 Mouse Monoclonal, Anti-Human IL-1β   Detection: 10139-MM09 Mouse Monoclonal, Anti-Human IL-1β Recommended ELISA Antibodies 10139-R012 Rabbit Monoclonal, Anti-Human IL-1β   10139-R101 Rabbit Monoclonal, Anti-Human IL-1β     +1-215-583-7898 | order_us@sinobiological.com 1400 Liberty Ridge Drive, Suite 101, Wayne, PA 19087

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